p16/MTS1基因缺失在骨髓增生异常综合征发病中作用的研究

Deletion of p16/MTS1 gene in myelodysplastic syndrome(MDS):Correlation with pathogenesis

目的 探讨多肿瘤抑制基因缺失 (multipletumorsup pressorgene 1,p16 /MTS1)与骨髓增生异常综合征(myelodysplasticsyndrome,MDS)发病的关系。方法 采用PCR方法 ,对 2 9例MDS的 p16 /MTS1基因的缺失情况进行分析 ,讨论其与疾病发生的关系。结果 2 9例MDS患者未见有 p16基因缺失。 结论 p16基因缺失和MDS的发病关系不大。

Objective To investigate the relationship between deletions of multiple tumor suppressor gene-p16/MTS1 gene and pathogenesis of MDS. Methods p16 gene was analysed by polymerase chain reaction in 29 MDS and correlated with pathogenesis. Results No p16 gene deletions were found in 29 samples. Conclusion The deletion of p16 gene shows little association with pathogenesis of MDS.