米非司酮对体外培养子宫肌瘤细胞的作用

Effect of Mifepristone on Human Leiomyoma Cell in vitro

目的 了解米非司酮对体外培养子宫肌瘤细胞的作用。方法 采用MTT法检测应用米非司酮前后子宫肌瘤细胞的体外生长情况。结果 米非司酮对子宫肌瘤细胞的抑制作用仅在达到一定浓度 (1 0 -5mol/L)时才表现出来 ,并且随着浓度的增加 ,其抑制作用呈线性增强。

Purpose To observe the effect of mifepristone on the human leiomyoma cells in vitro . Methods The growth of the cells was detected by MTT[3?(4,5 dimethylthiazol yl)?2?5 diphenyltetrazo lium bromide]Assay. Results The inhibitory effect of Mifepristone on the cells was only expressed when the concentration of mifepristone is relatively high (10 -5 mol/L). Conclusions The effect of mifepristone on the cultured human leiomyoma cells depends on the concentration of the reagent.This may supply some suggestion for the clinicians.