3Chambers G, Lawrie L, Cash P, et al. Proteomics:a new approach to the study of disease. J Pathol,2000 ,192 :280-288.
4Posadas EM, Simpkins F, Liotta LA, et al. Proteomic analysis for the early detection and rational treatment of cancer-realistic hope? Ann Oncol,2005,16 : 16-22.
5Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med ,1988,319:525-532.
6Perkins DN, Pappin DJ, Creasy DM, et al. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis, 1999,20 : 3551-3567.
7Bellacosa A. Genetic hits and mutation rate in colorectal tumorigenesis:versatility of Knudson's theory and implications for cancer prevention. Genes Chromosomes Cancer,2003,38:382-388.
8Moll R. Molecular diversity of cytokeratins: significance for cell and tumor differentiation. Acta Histochem Suppl, 1991,41 : 117-127.
9Polley AC, Mulholland F, Pin C, et al. Proteomic analysis ,reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Res, 2006,66 : 6553-6562.
10Alfonso P, Nuez A, Madoz-Gurpide J, et al. Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis. Proteomics, 2005,5:2602 -2611.
