摘要
在微波照耀和没有溶剂的条件下面,稀土元素的金属氯化物(RECl3 ) 是有效催化剂让喹啉衍生物的一个壶合成交上产品对通过醛,胺,和炔属羟的多部件反应的优秀收益好。没有催化活动的著名损失,稀土元素的金属氯化物能在六次被再循环。这条新合成途径有一短反应时间,产品的高收益,运作的简洁,宽广底层范围,环境地友好的性质和商业地可得到的催化剂的突出的特征。它在器官的合成作为催化剂扩大稀土元素的金属混合物的应用。
Under microwave irradiation and solvent-free conditions, rare-earth metal chlorides (RECl3) have been efficient catalysts for one-pot synthesis of quinoline derivatives to give products in good to excellent yields through the mul- ti-component reactions of aldehydes, amines, and alkynes. The rare-earth metal chlorides can be recycled for six times without notable loss of catalytic activities. This new synthetic approach has prominent features of a short re- action time, high yields of products, operational simplicity, broad substrate scopes, environmentally friendly prop- erty and commercially available catalysts. It extends the applications of rare-earth metal compounds as catalysts in organic synthesis.
基金
The work was supported by the National Natural Science Foundation of China (21172004, 21172003 and 21072004), the National Basic Research Program of China (2012CB821604), and grants from the Ministry of Education (20103424110001).