摘要
Copper hydride-catalyzed conjugate reduction-intermolecular aldol addition domino reactions were realized using α,β-unsaturated carboxylates as hydride acceptors and a silane as the reducing reagent. High diastereoselec- tivities were achieved with 4,5-bis（diphenylphosphino）-9,9-dimethylxanthene as the ligand and tert-butyl acrylate as the hydride acceptor.
Copper hydride-catalyzed conjugate reduction-intermolecular aldol addition domino reactions were realized using α,β-unsaturated carboxylates as hydride acceptors and a silane as the reducing reagent. High diastereoselec- tivities were achieved with 4,5-bis（diphenylphosphino）-9,9-dimethylxanthene as the ligand and tert-butyl acrylate as the hydride acceptor.
