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TCF7L2基因多态性与2型糖尿病关系的研究进展

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摘要 2型糖尿病是一种遗传与环境因素相互作用所致的疾病,具有明显的遗传倾向性。自2006年初Grant等发现转录因子7类似物2(TCF7L2)基因的多态性与T2DM显著相关以来,相关研究陆续在不同种族和人群中进行,阳性结果不断被证实。目前认为TCF7L2是迄今发现的与2型糖尿病发病关联最强的基因,近年来研究热点主要集中在rs7903146、rs12255372、rs11196205和rs11196218等位点。本文对该基因的研究现状及趋势进行综述。
作者 种琨瑛 常向云
机构地区 石河子大学医学院第一附属医院内分泌科
出处 《农垦医学》 2012年第5期437-440,共4页 Journal of Nongken Medicine
关键词 转录因子7类似物2(TCF7L2) 单核苷酸基因多态性(SNPs) 2型糖尿病(T2DM)
分类号 R587.1 [医药卫生—内分泌] Q754 [生物学—分子生物学]
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参考文献9

  • 1边澈,李佳,张晓蕾,刘巍,纪红梅.转录因子7样2基因rs290487-T/C多态性与2型糖尿病患者胰岛素抵抗的相关性[J].中国生物制品学杂志,2012,25(8):1017-1020. 被引量：5
  • 2Schafer SA, Tschritter O, Machicao F, et al. Impaired glucagon- like peptide-1 induced insulin secretion in carriers of transcription factor 7-like 2 ( TCFTL2 ) gent polymorphisms [ J ]. Diabetolo- gia,2007,50(12) :2443 -2450.
  • 3Shu L, Matveyenko AV, Kerr-Conte J,et al. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with down reg- ulation of GIP-1 and GLP-1 receptors and impaired beta-cell func- tion [ J ]. Hum Mol Genet,2009,18 ( 13 ) :2388 - 2399.
  • 4Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7 L2- dependent Wnt signaling enhances pancreatic beta cell prolifera- tion [ J]. Biol Chem,2008,283 ( 13 ) :8723- 8735.
  • 5Shu L, Sauter NS, S chulthess FT, et al. Transcription Factor 7- Like 2 regulates β-cell survival arid function in human pancreatic islets[ J]. Diabetes,2007,57:645 -653.
  • 6张留伟,陈大方.TCF7L2和KCNQ1基因多态性与2型糖尿病易感性的Meta分析[J].中国慢性病预防与控制,2010,18(6):554-559. 被引量：1
  • 7Yi F,Brubaker PL,Jin T. TCF-4 mediates cell type-specific regula-tion of proglucagon gene expression by beta-catenin and glycogensynthase kinase-beta [J] . Biol Chem,2005 ,280 ( 2 ):1457.
  • 8Elbein SC, Chu WS, Das SK, et al. Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African de- scent [ J ]. Diabetologia ,2007,50 ( 8 ) : 1621 - 1630.
  • 9Horikoshi M, Hara K, Ito C, et al. A genetic variation of the tran- scription factor 7-like 2 gene is associated with risk of type 2 diabe- tes in the Japanese population [ J ]. Diabetologia, 2007,50 ( 4 ) : 747 - 751.

二级参考文献38

  • 1Yasuda K, Miyake K, Horikawa Y, et al. Variants in KCNQI are associated with susceptibility to type 2 diabetes mellitus [J]. Nat Genet, 2008, 40: 1092-1097.
  • 2Warth R, Garcia AM, Kim J, et al. The role of KCNQ1/KCNE 1 K+ channels in intestine and pancreas: lessons from the KCNE1 knock out mouse[J]. Eur J Physiol, 2002, 443: 822-828.
  • 3Hiroyuki U, Atsushi T, Takahisa K, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations [J]. Nature Genetics, 2008, 40: 1098-1102.
  • 4Lee YH, Kang ES, Kim SH, et al. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FFO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population[J]. J Hum Genet, 2008, 53: 991-998.
  • 5Han XY, Luo YY, Ren Q, et al . Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQI, and WFS1 in type 2 diabetes in a Chinese population [J]. BMC Medical Genetics, 2010, 11:81.
  • 6Liu Y, Zhou DZ, Zhang D, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of China's Mainland [ J ]. Diabetologia, 2009, 52:1315 - 1321.
  • 7Hu C, Wang C, Zhang R, et al. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population [J]. Diabetologia, 2009, 52:1322-1325.
  • 8Chen Z, Zhang XF, Ma GS, et al. Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population [J]. Mol Biol Rep, 2010, 37:207- 212.
  • 9Fumihiko T, Masakuni S, Ken Y, et al . Continuation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population [J]. DIABETES, 2009, 58:1690- 1699.
  • 10Qi QB, Li HX, Loos RJF, et al. Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population[J]. Human Molecular Genetics, 2009, 18: 3508-3515.

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农垦医学
2012年 第5期

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