肥胖发病机制及其治疗靶点

Obesity Pathogenesis and Therapeutic Target

人体摄入的食物提供的能量用来维持各种生理和体力活动的正常进行。在生理状态下,能量代谢保持动态平衡,即摄入能量=消耗能量+贮存能量。当由于某种原因打破这一平衡使能量的摄入大于消耗时,机体储能的主要器官--脂肪组织内脂肪(主要为甘油三酯)堆积,体重超过标准体重20%以上者,称为肥胖。随着社会经济的发展和人民生活水平的提高,全球范围内超重/肥胖率急剧增加。肥胖与高甘油三酯血症、高血压、糖尿病在发病机理上密切相关,这些慢性疾病相互影响并常在同一个体聚集存在,肥胖引起的这种交互紊乱更是诱发和加重心脑血管疾病的重要危险因素。因此,研究和分析与肥胖相关的因素及相互关系,有助于肥胖的预防和治疗。

Human intake of food energy is used to maintain the physiological and physical activity of normal.Under physiological conditions,energy metabolism maintains dynamic balance,namely the energy intake equal energy consumption and energy storage.When there is for some reason to break the balance,the energy intake is more than consumption,and the energy storage of major organs-within adipose tissue fat（triglyceride accumulation mainly）.Weighing more than the standard weight of more than 20% persons,known as obesity.With the development of social economy and the improvement of people’s living standard,globally overweight / obesity rate increased dramatically.Obesity and hypertriglyceridemia,hypertension,diabetes in the pathogenesis of closely related,these chronic diseases affect each other and often occur in the same individual aggregation.his interaction disorder caused by obesity becomes important risk factor which induce and aggravate cardiovascular disease.Therefore,study and analysis of obesity related factors and their mutual relations is contribute to obesity prevention and treatment.