血清S100β,内皮素-1和血管内皮生长因子测定在老年认知功能障碍疾病诊断中的意义

Significance of S100β, Endothelin-1 and Vascular Endothelial Growth Factor in the Elderly Cognitive Dysfunction

目的：老年认知功能障碍尤其老年轻度认知功能障碍的早期诊断仍有一定的困难,本研究通过观察血清S100β,内皮素-1（ET-1）和血管内皮生长因子（VEGF）测定在老年认知功能障碍疾病诊断的意义。方法：选取2008年10月~2012年4月对我院的认知功能障碍的患者117例,其中阿尔茨海默病患者（AD组）55例和轻度认知功能障碍患者（MCI组）有62例。选取同期在我院体检的健康老年志愿者（对照组）20例。分别检测血清S100β,ET-1,VEGF和蒙特利尔认知评分（MoCA）。结果：血清S100β和ET-1水平,从AD组,MIC组和对照组依次降低,而VEGF水平和MoCA评分依次升高,差异有统计学意义（P〈0.01）。AD组患者血浆S100β,ET-1与MoCA评分存在负相关（r=-0.387,r=-0.408,P〈0.05）,AD组患者血浆VEGF与MoCA评分呈正相关（r=0.363,P〈0.05）;而MIC组患者血浆S100β,ET-1,VEGF水平与MoCA之间无明显相关性（P〉0.05）。结论：S100β,ET-1和VEGF参与老年认知功能障碍的形成过程,血浆S100β,ET-1水平与AD的病情正相关,血浆VEGF与AD的病情成负相关,对于早期发现MCI,和检测AD疾病的病情具有重要意义。

Objective： There are still some difficulties in the diagnosis of the elderly cognitive dysfunction,especially the mild cognitive dysfunction early,the significance of S100β,endothelin-1（ET-1） and vascular endothelial growth factor（VEGF） in the elderly cognitive dysfunction were observed in this study.Methods： 117 patients with elderly cognitive dysfunction from October 2008 to April 2012,were divided into AD group（55 cases with Alzheimer＇s disease） and MCI group（62 cases with mild cognitive impairment）.20 healthy elderly volunteers（control group） were selected at the same period.The levels of S100β,ET-1,VEGF and Montreal cognitive score（MoCA） were detected.Results： The serum levels of S100β and ET-1,from AD group and MIC group to control group in turns,reduced significantly.Meanwhile,the levels of VEGF and MoCA score increased,the difference was statistically significant（P 0.01）.The levels of S100β and ET-1 in AD group were negatively correlated to the MoCA score（r =-0.387,r =-0.408,P 0.05）,and the levels of VEGF was positively correlated to the MoCA score（r = 0.363,P 0.05）;Meanwhile,the levels of S100β,ET-1,VEGF in MIC group was no significant correlation to the MoCA score（P 0.05）.Conclusions： The S100β,ET-1 and VEGF participate in the formation process of the elderly cognitive dysfunction.The plasma of S100β and ET-1 showed a positive correlation with AD condition,and VEGF showed negative correlation with AD condition,monitoring of these indicators can be used to judge the severity of AD,it is of important significance to the early detection of MCI.