孕期大鼠暴露PFOS对胎鼠肝脏毒性的影响

Pregnancy Rats Exposure to PFOS is Associated with Lier Toxicity in Fetal Rats

目的:研究在孕期暴露PFOS对胎鼠的肝脏毒性的影响。方法:将孕期为12天的16只SD雌性大鼠,随机分为4组给予不同剂量的PFOS[0(对照),5,10,20 mg.kg-1],连续灌胃7天,在GD19天时对母鼠和胎鼠的体重、胎鼠肝脏的生化指标、母鼠血清的生化指标进行了相应的检测。结果:与对照组相比,母鼠体重在20 mg.kg-1组显著下降(P<0.001);胎鼠的体重和体长在20mg.kg-1组显著下降(P<0.001);胎鼠的肝脏重量降低,呈剂量依赖性,并伴有肝细胞浊肿、变性甚至坏死;10 mg.kg-1组胎鼠肝脏中的酶活性(ALT、AST、GGT和ALP等)显著升高(P<0.001);母鼠血清的大部分生化指标未发生明显变化。结论:孕期大鼠暴露在PFOS的环境下会严重损伤胎鼠的肝脏功能。

Objective： To study whether Pregnancy rats exposure to PFOS is related to the alteration of the Lier toxicity of Fetal rats.Methods： At gestational day（GD） 12,The Pregnancy rats were exposed to different doses of PFOS（0,5,10 and 20 mg·kg-1） by gavage for 7 days.The Body weight,the liver biochemical index of fetal rats,the serum biochemical index of Pregnancy rats were measured at GD19 in each dose group.Results： The body weight of Pregnancy rats exposed to 20 mg·kg-1 of PFOS were significantly lower than the control group（P0.001）;the body weight and length of Fetal rats exposed to 20 mg·kg-1 of PFOS were significantly lower than the control group（P0.001）;Fetal rats liver weight markedly decreased with the increase of PFOS dose,and with liver cell turbidity is swollen,degeneration or necrosis;PFOS at 10 mg·kg-1 increased Fetal rats liver enzyme activities（ALT,AST,GGT and ALP）（P0.001）;the serum biochemical index of Pregnancy rats did not change significantly.Conclusion： Pregnancy rats exposure of PFOS will serious damage the liver function of Fetal rats.