进展性脑卒中患者血清IL-6、TNF-2的动态变化及还原型谷胱甘肽对其的影响

Dynamic changes of interleukin-6 and tumor necrosis factor in progressive stroke patients and its impact on reduced glutathione

目的:探讨血清白介素-6﹑肿瘤坏死因子等炎性因子在进展性脑卒中不同时间段的动态变化及还原型谷胱甘肽对其的影响。方法:72例进展性脑卒中患者根据是否应用还原型谷胱甘肽分为观察组(39例)、对照组(33例),应用酶联免疫吸附测定法检测用药前及用药后6、12、24、48h血清白介素-6及肿瘤坏死因子水平,并进行比较。结果:两组用药前上述因子差异无统计学意义,用药后6h两组上述指标变化均不明显,差异无统计学意义(P>0.05),用药后12h观察组炎性因子水平均明显低于对照组,且差异有统计学意义(P<0.05),24h后观察组炎性因子水平进一步降低。结论:进展性卒中患者血清炎性因子随时间变化明显升高,还原型谷胱甘肽可以明显降低进展性脑卒中患者血清炎性因子水平,随时间延长其效果更加明显。

Objective： To study the dynamic changes of serum interleukin 6,tumor necrosis factor of progressive stroke patients during different time and the effects on glutathione.Methods： A total of 72 progressive stroke patients were divided into observation group（n=39）,control group（n=33）,according to administration of reduced glutathione.Serum interleukin 6 and tumor necrosis factor levels were determined by enzyme linked immunosorbent before administration and 6 h,12 h,24 h,48 h after administration.Results： Before treatment,the factors between two groups had no significant difference,and the difference was also not significant 6 h after administration（P0.05）.12 h after administration,inflammatory factor level in observation group was significantly lower than that of control group,and the difference was statistically significant（P0.05）,after 24 h,the inflammatory factor level in observation group was further reduced.Conclusions：Serum inflammatory factors significantly increase with time in progressive stroke patients.Reduced glutathione can obviously reduce the serum inflammatory factor level,and the longer the time is the better its effect is.