伊立替康与拓扑替康单药治疗老年小细胞肺癌临床分析

Effect of irinotecan and topotecan on old small cell lung cancer

目的:探讨伊立替康(CPT-11)和拓扑替康(TPT)治疗老年小细胞肺癌的疗效及不良反应是否有差别。方法:回顾性分析156例经病理确诊的老年小细胞肺癌,其中CPT-11组88人,TPT组68人;比较两组的疗效及反应。结果:两组之间在近期疗效和远期疗效上均无统计学差异(P>0.05);TPT组白细胞减少高于CPT-11组,差异有统计学意义(P<0.05);而在延迟性腹泻中,CPT-11组高于TPT组,差异有统计学意义(P<0.05);在贫血、血小板减少、恶心呕吐及肝功能异常中,差异无统计学意义(P>0.05)。结论:CPT-11组及TPT组化疗的近期、远期疗效相似,血液毒性反应中,CPT-11组优于TPT组;肠道反应中,TPT组优于CPT-11组。

Objective： To explore the curative effect and side effects of CPT-11 and TPT treatment on small cell lung cancer（SCLC）.Methods： A total of 156 SCLC patients were divided into CPT-11（n=88） and TPT group（n=68）.Efficacy was observed and compared.Results There was no significant difference in short-term curative effects and long-term among curative effects between the two groups（P0.05）.Incidence of leucopenia in TPT group was significantly higher than CPT-11 group（P0.05）.Incidence of delayed diarrhea in CPT-11 group was significantly higher than TPT group（P0.05）.There was no significant difference in incidence of anemia,thrombocytopenia,nausea vomiting nor abnormal liver function（P0.05）.Conclusion： There is no significant difference in short-term curative effects and long-term among curative effects between the two groups;CPT-11 is better than that of TPT group in blood toxicity reaction;TPT group is better than the CPT-11 group in gut reaction.