不同透析液对腹膜透析患者残余肾功能与透析充分性的影响

Influence of different dialysate on residual renal function and dialysis adequacy on peritoneal dialysis patients

目的探讨不同腹膜透析液对腹透患者残余肾功能与透析充分性的影响。方法回顾性分析2008年1月～2009年12月我院行腹膜透析治疗、分别使用进口和国产腹膜透析液的患者,随访两年期间能定期行透析充分性及腹膜平衡试验的患者,比较两组患者残余肾功能、透析充分性及腹膜转运类型变化等指标。结果两种腹膜透析液在患者残余尿量、肾小球滤过率、周尿素氮清除指数(KT/V)、周肌酐清除率(CCr)、4小时肌酐透出液与血浆比(D/P)值、腹透超滤量均无显著性差异(P>0.05)。结论该国产腹透析液对小分子溶质和水的清除,残余肾功能和腹膜转运功能的影响与进口腹透液是相当的,并没有引起血钠浓度的升高。

Objective To investigate the effect of different dialysate on residual renal function and dialysis adequacy on peritoneal dialysis patients. Methods Routinely follow-up patients who had peritoneal dialysis catheter implantation from Jan 2008 to Dec 2009 were enrolled in this study. They were divided into two groups by the imported and domestic dialysate. Residual renal function, dialysis adequacy and transport type of peritoneum were collected and compared between two groups. Results There were no significant difference between two groups in residual urine volume, glomerular filtration rate, weekly KT/V, weekly creatinine clearance rate （Ccr）, dialysate to plasma ratios of creatinine at 4h and net ultrafiltration. Conclusion Domestic dialysate is equivalent to imported dialysate in clearance of small molecular solute and water, effect on renal residual function and peritoneal transport function. Hypernatremia were not observed in domestic dialysate group.