武汉市孕妇及新生儿维生素D水平的现状调查

Analysis of the Vitamin D level of the pregnant women and newborns in Wuhan City

目的探讨武汉市孕妇及新生儿维生素D水平,研究孕期维生素D缺乏与新生儿先天性佝偻病的相关性,为孕期补充维生素D提供理论依据。方法膳食调查法研究孕妇食物摄取的维生素D,放免法测定孕妇血清以及新生儿脐血维生素D水平,确定新生儿是否患有先天性佝偻病。结果武汉市孕妇通过食物摄取的维生素D量为(172±56)IU/d。孕妇血清平均维生素D水平为23.7nmol/L,维生素D水平随孕周增加递减。不同季节孕妇维生素D水平为:夏季高于春、秋、冬季。孕妇中维生素D缺乏率为5.7%。新生儿先天性佝偻病的发病率为14%。孕妇分娩前维生素D水平与新生儿先天性佝偻病呈负相关(P<0.05)。结论武汉市孕妇维生素D摄入不足,新生儿先天性佝偻病的发病率较高,孕期应加强维生素D的摄入。

Objective To investigate Vitamin D status of pregnant women and newborns of Wuhan City and to assess the relationship of viamin D dificiency of pregnant women to the congenital rickets. Methods Food intake of vitamin D of pregnant women was measured by dietary survey. Vitamin D status of pregnant women and umbilical cord was test- ed by radioactive immunoassay. Whether newborns were suffered from conginital rickets was estimated by pediatricians. Results Food intake of vitamin D of pregnant women was （172±56）IU/d. Mean vitamin D level of pregnant women was 23.7nmol/L. Vitman D status was decreased with the gestation. Vitamin D status was different between seasons., summer〉spring〉autumn〉winter. Vitamin D dificieney rate of pregnant women was 5.7%. Conginital rickets rate of new- borns was 14%. Conginital rickets of newborns was negatively related to the status of pregnant women before delivery. Conclusion Pregnant women vitamin D intake of Wuhan City was insufficient. Vitamin D insufficient of pregnant women could lead to congenital rickets. Pregnant women should enhance vitamin D intake.