低分子肝素超早期干预对DIC发生率的影响

Discuss the effect on the incidence of DIC with ultra-early intervention of LMWH

目的研究对有DIC(disseminated intravascular coagulation,弥散性血管内凝血)高发因素的重症患者超早期应用低分子肝素(Low-Molecular-Weight Heparins Calcium Injection,LMWH)能否减少DIC的发生率。方法选择有DIC高发因素的重症患者46例随机分为2组,对照组按相应疾病诊疗常规治疗,LMWH超早期干预组在对照组方法治疗的基础上,在出凝血机制无明显障碍的前提下,入院即给予低分子肝素皮下注射2次/日。观察两组患者10天内DIC发生情况的差异。结果 LMWH超早期干预组发生DIC 1例(4.4%),对照组6例(26.1%)。对照组DIC发生率明显高于LMWH组,组间差异有显著性(P<0.05)。结论对有DIC高发因素的重症患者超早期应用低分子肝素治疗,能有效减少DIC的发生率,提高重症患者的存活率。

Objective To research the ultra-early intervention of LMWH （Low Molecular Weight Heparins Calcium Injection） in the severe case with high risk factors of cause DIC （disseminated intravascular coagulation） whether reduce the incidence of DIC. Methods 46 cases of patients with high risk factors of DIC were included and randomly divided into 2 groups. The control group was abided to the corresponding disease clinic routine treatment. Under the premise of no disorders of blood coagulation mechanism and based on the treatment of control group, give subcutaneous injection of LMWH to the ultra-early intervention group of patients 2 times per day. Observe the deference of the incidence cases of DIC between two groups of patients within 10 days. The results are analyzed by test. Results DIC occurred in 1 cases in the ultra-early intervention group and 6 cases in the control group. The incidence of DIC is 4.4% in the ultra-early in- tervention group and 26.1% in the control group. In control group the incidence of DIC was higher than that of LMWH group. In two groups of patients with the incidence of DIC had significant difference （P〈0. 05）. Conclusion The Ultra early intervention of LMWH in the severe case with high risk factors of DIC can effectively reduce the incidence of DIC and improve the survival rate of severe patients.