摘要
目的探讨血清谷氨酸脱羧酶抗体(GADA)在慢性乙型肝炎临床诊疗中的价值。方法对我院收治的118例慢性乙型肝炎患者进行治疗,治疗前采用ELISA法检测118例慢性乙型肝炎患者(观察组)及30例同期健康者(对照组)血清GADA阳性率,治疗12周后对患者的康复情况进行评价分组,同时检测每组GADA的阳性率;观察慢性乙型肝炎和健康者的GADA阳性率差异及GADA阳性率同慢性乙肝严重程度的关系。结果观察组患者血清GADA阳性率显著高于对照组(P<0.05),所有患者经治疗后康复情况越好,则GADA阳性率越低。结论 GADA阳性率可作为慢性乙型肝炎的临床判断指标之一,同时也可作为病情严重程度的评价指标。
Objective To explore the value of serum glutamie acid deearboxylase antibody in the diagnosis of chronic hepatitis B. Methods 118 patients with chronic hepatitis B patients treated in our hospital were included as the observation group, and the healthy volunteers as the control group. The serum GADA positive rate was detected by ELISA method before treatment, patients were divided into three groups after 12 weeks of treatment, the GADA positive rate in the serum of these three groups of patients were detected. The serum GADA positive rate difference was observed in the observation group and the control group, the serum GADA-positive rate and severity relationship was also observed. Results There was significant difference of GADA between the observation group and the control group （P〈0.05）. Significant difference was found in serum GADA among these three groups. Conclusion The serous GADA positive rate can be as diagnostic indicators of chronic hepatitis B and the evaluation of the severity of the disease.
出处
《西部医学》
2013年第5期763-764,766,共3页
Medical Journal of West China
