硒对桥本甲状腺炎患者TPOAb及TGAb水平的影响

The Effect of Selenium on Thyroid Peroxidase Antibody and Thyroglobulin Antibody in Hashimoto Thyroiditis

目的：观察硒对桥本甲状腺炎（HT）患者甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）的影响。方法：选取TPOAb在100～600IU／ml之间，TGAb在200IU／ml到2000IU／ml之间的HT患者66例，随机分为硒治疗组与对照组，硒治疗组（n=46）服硒酵母片（100I．Lg，2次，d）和左甲状腺素钠片（维持TSH至O．27～4．2μIU／m1）治疗；对照组（n=20）服左甲状腺素钠片（维持TSH至0．27—4．2μIU／m1）治疗，比较两组治疗3个月后TPOAb及TGAb水平的变化。结果：治疗3个月后两组TGAb水平与治疗前相比，差异无统计学意义（P〉0．05）。治疗3个月后，两组TPOAb水平明显降低，但降低值差异无统计学意义（P〈0．05）。结论：硒对桥本甲状腺炎患者轻度增高的TPOAb及TGAb水平无明显影响。

Objective： To observe the effect of selenium on thyroid peroxidase antibody （ TPOAb ） and thyroglobulin antibody （ TGAb ） in patients with Hashimoto thyroiditis （ HT ） .Method： 66 patients with HT whose TPOAb levels were between 100 IU/ml and 600 IU/ml, TGAb levels were between 200 and 2000 IU/ml were randomized into selenium treatment group and control group.The selenium treatment group （ n=46 ） received selenium yeast 200 μg per day , plus L-thyroxine to maintain TSH levels between 0.27-4.2μIU/ml ; the control group received L-thyroxine to maintain TSH levels between 0.27-4.2 μIU/ml.After 3 months compared the changes of TPOAb and TGAb levels in the two groups.Result： There were no significant changes of TGAb levels after 3 months of treatment compared with before treatment in the two groups （ P〉0.05 ） .There were significant decrease of TPOAb levels after 3 months in the two groups, but the reduction had no significant difference between the two groups.Conclusion： Selenium has no significant effect on slightly increased TPOAb and TGAb levels in HT.