儿童呼吸道感染快速肺炎支原体培养及药敏检测分析

Rapid culture and drug sensitivity test of Mycoplasma pneumopniae in children with respiratory tract infection

目的调查在2011~2012年,乌鲁木齐地区儿童呼吸道感染者中,肺炎支原体（Mycoplasma pneumoniae,MP）感染及药敏情况。方法在2011年9月至2012年8月,收集新疆维吾尔自治区人民医院儿科门诊和住院的呼吸道感染患儿咽拭子1299例,使用快速MP分离培养药敏试剂盒,进行MP快速分离培养,同时进行对红霉素、罗红霉素、克拉霉素、阿奇霉素、乙酰螺旋霉素、克林霉素、左氧氟沙星、加替沙星、司帕沙星9种抗生素的药敏实验。结果1299例儿童呼吸道感染者中MP检出率为13.70%（178/1299）。MP感染全年均可发生。MP感染在民族、年龄及性别方面比较均无统计学差异。MP对阿奇霉素、左氧氟沙星、加替沙星和司帕沙星的敏感率高。结论MP感染为乌鲁木齐地区儿童呼吸道感染的主要病因之一,快速MP培养及药敏实验结果,可以协助临床病因诊断,指导医师选择敏感药物治疗。

Objective To investigate the infectious condition and drug sensitivity of Mycoplasma pneumoniae in children with respirotary infection in Xinjiang Uygnr Autonomous Region. （Mycoplasma pneumoniae, MP） from 2011 to 2012. Meth- ods Pharyngeal swabs were collected from 1 299 out-patient children with respiratory tract infection in Xinjiang Uygur Au- tonomous Region People＇s Hospital from Sep.2011 to Aug. 2012,for rapid culture and drug sensitive tests of MP to 9 antibiotics （erythromyein, roxithromycin,clarithromyein,azithromycin,acetylspiramycin,Cclindamycin, evofloxacin,gatifloxacin,sporfloxa- cin）. Results Totally 178 positive cases were detected with a positive rate of 13.70%, MP infection can occur throughout the year, there were no differences in natiionality, age and gender. The sensitive rates of MP to azithromycin, levofloxacin, gatifloxa- ein and sparfloxaein were high, the resistance rate of MP to roxithromycin was the highest. Conclusions MP infection was one of the main causes in children with respiratory tract infection in Urumqi area, rapid MP culture and drug sensitive tests may assist clinical diagnosis, guide the physician to select sensitive drugs to treat patients.