绵阳市228例艾滋病感染者和病人CD4^+T淋巴细胞检测分析

Detection of CD4^+T lymphocytes from 228 HIVcarriers and AIDS patients in Mianyang city,Sichuan province

目的检测HIV感染者或病人CD4+T淋巴细胞,了解免疫重建时机,分析检测的影响因素。方法对绵阳市2007~2010年艾滋病感染者或病人共228例用贝克曼流式细胞仪按《全国艾滋病防治规划》要求进行CD4+T淋巴细胞检测,并对经静脉吸毒传染者、男男同性接触传染和异型性接触传染三类人群CD4+T淋巴细胞进行分析。结果接受HAART的病人63.2%以上免疫重建较好;三类人群CD4+T淋巴细胞计数比较存在差异。结论当CD4+T细胞计数较高(>200个/μl或>350个/μl)时接受抗病毒治疗免疫重建较好;CD4+T淋巴细胞计数较低和变化幅度较大时,临床医生应结合病毒载量及临床症状综合分析。

Objective To analyze CD4 ＋ T lymphocytes in 228 HIV carriers and AIDS patients.Methods The CD4 ＋ T lymphocytes in 228 HIV/AIDS patients in Mianyang city were detected using BeckMan flow cytometry from 2007 to 2010 according to the national AIDS control program.Meantime the CD4 ＋ T lymphocytes in drug users through intravenous injection,male homosexuals and heterosexuals were also detected.Results The immune reconstruction of over 63.2% patients treated with HAART were relatively good,but the lymphocyte counts in the drug suers,male homosexuals and heterosexuals were different associated with a number of factors.Conclusions The immune reconstitution might be good when the HIV/AIDS patients accepting antiviral treatment and the level of CD4 ＋ T cells was high（200 个 /μl or 350 个 /μl）.The clinicians should take the viral load into consideration in case the levels of CD4 ＋ T lymphocytes was low or varied greatly.