肺炎支原体肺炎患儿体液免疫变化及匹多莫德的治疗作用

Change of humoral immunity and therapeutical effect of pidotimod for children with Mycoplasma pneumoniae pneumonia

目的:探讨肺炎支原体体液免疫变化情况及匹多莫德的治疗作用。方法:将2008年12月～2010年12月收治的肺炎支原体肺炎患儿70例随机分为治疗组40例和对照组30例。两组均给予红霉素、阿奇霉素序贯治疗,治疗组同时口服匹多莫德400 mg,每日2次。检测两组的免疫球蛋白,并进行统计学分析。结果:治疗后治疗组患儿的IgG及IgA明显高于对照组,治疗组免疫球蛋白恢复正常。结论:支原体肺炎患儿存在体液免疫功能紊乱,匹多莫德有助于调节IgG及IgA水平。

Objective： To explore the change of humoral immunity and therapeutical effect of pidotimod for children with Mycoplas- ma pneumoniae （MP） pneumonia. Methods： Seventy children with MP pneumonia who were treated from December 2008 to December 2010 were randomly divided into treatment group （40 children） and control group （30 children） . The children in the two groups were trea- ted with sequential therapy （erythromycin plus azithromycin）, while the children in treatment group were treated with oral administration of pidotimod （400 mg）, twice a day. The levels of immunoglobin in the two groups were detected, and a statistical analysis was performed. Results： After treatment, the levels of IgG and IgA in treatment group were significantly higher than those in control group, the level of im- munoglobin in treatment group returned to normal level. Conclusion： Dysfunction of humoral immunity exists in the children with MP pneu- monia, pidotimod is helpful to regulate IgG and IgA levels.