湖北地区肠球菌耐药性观察

Observation to the antimicrobial resistance of enterococci in Hubei Province

目的：分析临床分离肠球菌对抗菌药物的耐药性。方法：对湖北地区１１所医院１９９８年１０月－ｌ９９９年 ９月临床分离肠球菌进行Ｋ－Ｂ药敏试验，用ＷＨＯＮＥＴ－４软件完成数据分析。结果：２５４株肠球菌中，粪肠球菌１８３ 株（７２．０％），屎肠球菌３８株（１４．９％）；肠球菌主要来自中段尿，其次为伤口、呼吸道、穿刺引流液。庆大霉素高耐 株、链霉素高耐株分离率分别为４７．３％和５６．０％，耐万古霉素肠球菌分离率５．３％。粪肠球菌对庆大霉素、氯霉素、 四环素、红霉素、克林霉素的耐药率均大于６０％，屎肠球菌对β－内酰胺类相对耐药，对庆大霉素、四环素、红霉素、环 丙沙星的耐药率为５１．６％－９２．３％。结论：肠球菌耐药尤其多重耐药严重。

Aim: To investigates the antimicrobial resistance of clinical isolates in enterococci.Methods:Susceptibility test was carried out by using Kirby-Bauer method. A WHONET-4 computer software was used to analyse tea data. Results:Enterococ- cus faecalis(efa) and enterococcus faecium(efm) occupied respectively 183 strains(72. 0%) and 38 strains (14. 9%) of 254 strains entrococci. Enterococcus. came from urine mainly, others from wound, respiratory tract and drainage fluid in order.Detection rates of high-level gentamycin resistance and high-level streptomycin resistance were 47.3% and 56.0% individually, the rate of vancomycin-resistant enterococci was 5. 3%.The percentage of resistance to gentamycin, chloromycin, tetracycline,erythromythin and clindamycin of efa was over 60%;the rates of efm to gentamycin, tetracycline, erythromycin and ciprofloxacin from 51.6% to 92. 3%, efm were more resistant to β－lactam antibiotics than efa. Conclusion: Infections of enterococci especially multi-drug resis- tant bacteria were serious.