286例男性不育患者细胞遗传学分析

Karyotype Analysis on 286 Cases with Male Infertility

目的研究男性不育与染色体核型异常的关系。方法对286例男性不育患者，抽取外周血进行淋巴细胞培养、G显带、核型分析。结果检出异常核型69例，异常检出率为24．13％。其中，52例为Klinefelter综合征，占异常核型的75．36％；9例为常染色体结构异常，占异常核型的13．04％；8例为Y染色体异常，占异常核型的11．59％。结论染色体异常是造成男性不育的重要因素之一，对临床上男性不育患者进行染色体检查非常必要。

Objective To study the relationship between male infertility and the abnormal chromosome karyotype. Methods Blood lymphocyte isolated from 286 cases with male infertility were cultured,G banding stained and analysed. Results 69 cases of abnormal karyotype were detected in 286 cases with male infertility. The rate of anomaly detection was 24. 13%. There were 52 cases of Klinefe lter syndrome,accounting for 75.36 ^ in all abnormal karyotypes. And there were 9 cases of chromosome structure abnormality which was 13. 04% in chromosome abnormalities. It also included 8 cases of Y chromo- some,accounting for 11.59% in all abnormal karyotypes. Conclusion Chromosomal abnormality is the main reason for patients with male infertility. It is necessary to take the karyotype analysis of chromosome in male infertility patients.