急性脑梗死患者血清IL-6与颈动脉粥样硬化的相关性

Correlation between Serum Levels of IL-6 and Carotid Artery Atherosclerosis in Patients with Acute Cerebral Infarction

目的探讨急性脑梗死患者血清IL-6水平与颈动脉粥样硬化之间的相关性。方法选择38例急性脑梗死患者为脑梗死组，同期健康者30例为对照组，检测血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、脂蛋白a、空腹血糖、高敏C反应蛋白和IL-6的含量，并应用彩色多普勒超声检查颈动脉粥样硬化斑块及颈动脉内膜-中膜厚度（IMT）。结果脑梗死组血清IL-6水平（24．2±7．9pg／ml）明显高于健康对照组（17．1±8．1pg／ml）（t=1.932，P〈0．05）；脑梗死组颈动脉IMT（1．20±0．34）mm高于对照组（1．03±0．20）mm（t=2．314，P〈0．05）；在急性脑梗死组中。血清IL-6水平与颈动脉IMT水平（r=0．412，P〈0．01）和hs—CRP水平（r=0．389，P〈0．05）呈显著正相关；多元线性逐步回归分析显示血清IL-6是急性脑梗死的重要危险因子之一。结论血清IL-6水平与炎性反应和颈动脉粥样硬化密切相关，是急性脑梗死强的危险预测因素。

Objective To investigate the correlation between serum levels of IL-6 and carotid artery atherosclerosis in patients with acute cerebral infarction （ACI）. Methods 38 patients with ACI were assigned as experimental group and 30 healthy people as control group. The serum level of IL-6 was measured, and the carotid plaques and the changes of cctrotid intimalmedial thickness （IMT） were examined by color doppler ultrasonography. Results The average level of IL-6 was significantly higher in ACI group （24.2 ± 7.9 pg/ml） than that of healthy control group （17.1 ± 8. 1 pg/ml） （t = 1. 932, P〈 0.05）. The increased carotid IMT were higher in ACI group than in control group [（1.20±0. 34）ram vs（1.03±0.20）mm, t=2. 314,P〈0.05]. In ACI group,IL-6 levels were correlated with carotid IMT （r=0. 412,P〈0.01） and hs-CRP （r= 0. 389,P〈0.05）. Multiple linear stepwise regression analysis showed that IL-6 was one of the important risk factors in ACI. Conclusion These findings showed IL-6 and Inflammatory reaction are risk predictors in the development of carotid artery atherosclerosis and especially its involvement in the progress of ACL .