化湿泄浊祛瘀法治疗湿浊瘀阻型慢性尿酸性肾病54例临床观察

Clinical Observation on Treatment 54 Cases of Chronic Uric- acid Nephropathy of Blood Stasis Type with Drugs for Purging Turbid, Resolving Dampness and Dispelling Phlegm

为了观察自拟化湿泄浊祛瘀汤治疗湿浊瘀阻型慢性尿酸性肾病(CUAN)的临床疗效。治疗组以化湿泄浊祛瘀汤加别嘌吟醇,对照组以单纯别嘌吟醇治疗,观察两组治疗前后血尿酸、肾功能、尿蛋白、尿系列微量蛋白、血脂及血粘度指标的变化。结果治疗组(54例)总有效率为92.59％,明显高于对照组(36例)63.89％的总有效率(P<0.01);治疗组在改善症状及肾功能,降低血尿酸、尿蛋白和尿系列微量蛋白,改善血脂代谢及血液高凝状态等方面均优于对照组(P<0.01)。表明化湿泄浊祛瘀汤能有效治疗湿浊瘀阻型CUAN。

A self-prescribed recipe of drug for purging turbid, Resolving Dampness and Dispelling Phlegm was employed in the treatment group (N = 54) with combination of allopurinol, and compared its effect with that in the control group (N = 36) only with allopurinol. The total effective rate in the treatment group (92.59%) was significantly higher (P<0. 01) than that of the control group (63. 89%). The levels of uric acid in the blood. urinary protein, microproteins after treatment demonstrated that renal function, lipid metabolism and hyperviscosity were also significantly improved (P < 0. 01). The authors concluded that this therapeutic principle is effective.