中西医结合治疗妊娠期外阴阴道假丝酵母菌病的临床观察

Treatment of vulvovaginal candidiasis in pregnancy with integrated Chinese and Western medicine

目的:对中西医结合治疗妊娠期外阴阴道假丝酵母菌病的临床疗效进行研究分析。方法:以2010年3月～2012年6月在我院进行孕期检查患有外阴阴道假丝酵母菌病的73例孕妇为研究对象,随机分成治疗组和对照组,治疗组36例,采用硝呋太尔制霉菌素阴道软胶囊联合中药熏洗外阴的方法进行治疗,对照组37例,采用2%小苏打水冲洗外阴道后联合硝呋太尔制霉菌素阴道软胶囊进行治疗,比较分析两组治疗后临床疗效及复发情况。结果:治疗组总有效率为91.6%,明显高于对照组72.9%,而复发率为3.03%,明显少于对照组25.9%(P<0.05),两组治疗前外阴瘙痒、灼痛、白带增多及外阴红肿的发生率相比差异无统计学意义(P>0.05),两组治疗后的外阴瘙痒、灼痛、白带增多及外阴红肿的发生率明显低于治疗前,相比差异有统计学意义(P<0.05),治疗组治疗后外阴瘙痒及白带增多的发生率均明显低于对照组,相比差异有统计学意义(P<0.05)。结论:中西药物联合局部用药治疗妊娠期外阴阴道假丝酵母菌病有效率高,复发率低,临床症状恢复快,值得临床推广应用。

Objectives： To study the clinical efficacy of vulvovaginal candidiasis in pregnancy treated with integrated Chi- nese and Western medicine. Methods： Totally 73 cases of pregnant women suffering from vulvovaginal candidiasis were confirmed in our hospital from March 2010 to June 2012. They were randomly divided into the treatment group and the control group. 36 pa- tients in the treatment group were treated with both Chinese traditional medicine and Nifuratel Nysfungin Vaginal Soft Capsules. 37 patients in the control group were treated with 2% baking soda and Nifuratel Nysfungin Vaginal Soft Capsules. The efficacy and recurrence of the two groups were analyzed. Results： The total effective rate in the treatment group was 91.6%, which was significantly higher than that in the control group （72. 9% ）. The recurrence rate in the treatment group was 3.03%, significantly lower than that in the control group （25. 9% ）, and the difference was statistically significant （P 〈 0. 05）. There was no statisti- cally significant difference in terms of the occurrence rate of pruritus vulvae, causalgia, leucorrhea increase and vulvar redness and swelling between the two groups before treatment （P 〉 0.05）. The incidence rate of pruritus vulvae, causalgia, leucorrhea increase and vulvar redness and swelling after treatment was significantly lower than that before treatment, and the difference was statistically significant （ P 〈 0. 05 ）. After the treatment, the incidence rate of pruritus vulvae and leucorrhea increase was signifi- cantly lower than that in the control group, and the difference was statistically significant （ P 〈 0. 05 ）. Conclusion ： The treat- ment of vulvovaginal candidiasis in pregnancy with integrated Chinese and Westem medicine features higher efficacy, lower recur- rence rate and more rapid recovery. It is worthy of clinical promotion.