影响糖尿病视网膜病变黄斑中心凹无血管区大小的因素初探

Exploration of the factors which affect the size of diabetic macular foveal avascular zone

目的 探讨糖尿病视网膜病变 (diabeticretinopathy ,DR )黄斑中心凹无血管区 (fovealavascularzone ,FAZ)大小的影响因素。 方法 对 79例非增生期及增生早期DR患者采用Heidelberg激光扫描眼底荧光造影系统测定其FAZ ,以糖尿病病史 10年为界将患者分为 10年以内、10年及其以上 2个亚组 ,按全国统一的DR分期标准将DR分为 4期 ,根据黄斑部荧光素渗漏情况将黄斑水肿分为局限性、弥漫性及囊样水肿 3种形态。分别分析不同糖尿病病程、DR程度及黄斑水肿形态患者的FAZ大小 ,并将结果进行方差分析或t检验。 结果 糖尿病病程与FAZ的大小无关 (t =1.385 4,P >0 .1) ;不同DR程度患者之间FAZ的大小差异有显著性意义 (F =7.6 2 5 1,P <0 .0 1) ;不同黄斑水肿形态患者之间FAZ的大小差异亦有显著性意义(F =5 .436 9,P <0 .0 1)。 结论 糖尿病患者FAZ的扩大程度随DR加重而增加 ,但与病程无关。

Objective To expolre the factors which affect the size of diabetic,macular foveal avascular zone(FAZ). Methods Making ten years of duration of diabetes a limit,79 nonproliferative and early proliferative diabetic patients were divided into 2 groups.Diabetic retinopathy severity level was diveided into 4 stages,and the macular edema was subdivided into focal、diffuse and cystoid according to fluorescein leakage of foveomacular region.All patients were measured FAZ with Heidelberg scanning laser fluoresceion angiography system and then compaired the size of FAZ of patients with different duration of diabetes、diabetic retinopathy severity level and macular edema status.The results were performed analysis of variance and t test. Results The study shown the size of FAZ was not directly related to the duration of diabetes(t=1.3854,P>0.1);There were significant differences about the size of FAZ of patients with different diabetic retinopathy severity level(F=7.6251,P<0.01) and macular edema status(F=5.4369,P<0.01). Conclusion The size of FAZ was significantly increased in diabetic patients.It was enlarged with the deve- lopment of diabetic retinopathy severity level,but it was not related to duration of diabetes.