影响溃疡性结肠炎复发的因素探讨

Study of Factors in the Recurrent of Ulcerative Colitis

目的探讨影响溃疡性结肠炎复发的相关危险因素。方法选择本院2005年3月至2012年6月确诊收治的溃疡性结肠炎患者188例,按照是否为初次就诊分为2组,84例复发患者纳入观察组,104例初次就诊者纳入对照组。比较两组患者的临床资料,将有统计学意义的因素纳入非条件Logistic多因素回归分析,确定危险因素。结果两组在吸烟史、酗酒史、喜食油炸食物、精神紧张、CRP升高、治疗依从性差和合并感染等方面差异显著(P<0.05),Logistic回归分析表明吸烟史是UC的保护性因素(OR=0.10,95%CI=0.04-0.55),喜食油炸食物(OR=2.40,95%CI=1.24-7.28)、精神紧张(OR=4.20,95%CI=1.81-11.27)和CRP升高(OR=1.74,95%CI=1.07-5.22)等3项是UC复发的独立危险因素。结论溃疡性结肠炎的复发受多种因素影响,其中吸烟史是其保护性因素,而喜食油炸食物、精神紧张和C反应蛋白升高是其独立危险因素,应针对性的采取预防措施。

Objective To investigate the influencing factors in the recurrent of ulcerative colitis. Methods 188 ulcerative colitis patients from March 2005 to June 2012 were divided into two groups, 84 patients in observation group were recurrence, 104 patients in control group were initial visit. Data of two groups were compared and significant factors were analyzed by Logistic. Results There was difference between two groups in history of smoking and alcohol abuse, eating fried food, mental stress, CRP, poor compliance for treatment and infection（P〈0.05）. Logistic analyzed showed that smoking was the protective factors of UC（OR=2.40,95%CI=1.24-7.28）, and eating fried food（OR=2.40,95%CI=1.24-7.28）, mental stress（OR=4.20,95%CI=1.81-11.27） and CRP（OR=1.74,95%CI=1.07-5.22） were the risk factors for UC recurrent. Conclusion Many factors can affect the UC recurrent, and smoking was the protective factors, eating fried food, mental stress and CRP are all risk factors, targeted prevention measures should be taken.