摘要
目的评价左氧氟沙星三联疗法根除幽门螺杆菌(Helicobacter pylori,HP)感染及治疗消化性溃疡的疗效。方法选择420例HP阳性消化性溃疡患者,随机分为治疗组,给予兰索拉唑(lansoprazole,L)30 mg,左氧氟沙星(Levofloxacin,L)500 mg,阿莫西林(Amoxicillin,A)1000 mg,2次/d,10 d为1个疗程。对照组,给予兰索拉唑30 mg,克拉霉素(Clarithromycin,C)500 mg,阿莫西林1000 mg,2次/d,10d为1个疗程。疗程结束后30 d后复查胃镜及Hp。结果治疗组和对照组Hp根除率各为93.3%,88.8%(P>0.05),溃疡愈合率分别为89.2%,84.4%。结论左旋氧氟沙星联合兰索拉唑和阿莫西林是一种安全、疗效高、耐受性好的治疗Hp感染的方案。
Objective Evaluate Objectively the clinical efficacy of triple therapy for HP-related peptic ulcer (PU) of the patients. Methods 420 cases of Hp-related peptic ulcer patients, were randomly divided into the treatment group and the control group 180 cases,treatment group received Levoflaxcin500m g+amoxicillinl000mg+Lansoprazole30mg,Bid,treatment 10day, control group, ClarithromycinS00mg+amoxicillin 1000rag+ lansoprazole30mg,Bid,treatment 10day.After stopped therapy 30 days,review gastroscope and Hp,and observe its effect. Results The Hp eradication rate ,the treatment group and the control group were 93.3%,88.8%(P〉0.05), the difference was not significant; the ulcer healing rate were 89.2%,84.4%.Conclusions Levofloxacinsea, amoxicillin, Lansoprazole triple therapy, is a kind of safty, high curative effect, tolerance good treatment scheme of Hp infection.
出处
《中国医药指南》
2013年第8期17-18,共2页
Guide of China Medicine