临床药物护理干预对缓解期精神分裂症患者的维持治疗及生存质量的影响研究

The Effect of Clinical Pharmaceutical Nursery Intervention on Maintaining Treatment and Quality of Life in Patients with the Recovery Schizophrenia

目的探讨临床药物护理干预对缓解期精神分裂症患者的药物维持治疗及生存质量的影响。方法将100例缓解期精神分裂症患者随机分为临床药物护理干预组和对照组各50例,两组均接受抗精神病药物治疗,而干预组合并药物护理干预措施,分别于入组时,入组后3个月、6个月、9个月、1年时进行简明精神病评定量表(BPRS)、WHO生存质量评定量表简表(WHOQOL-BREF)、治疗依从性、复发率和再住院率的评定。结果跟踪3个月到1年,干预组患者在WHOQOL的生理、领域、领域的评分显著高于对照组(P<0.05),治疗依从性明显高于对照组(P<0.01)。治疗依从性明显高于对照组(P<0.01)。结论临床药物护理干预保证了缓解期精神分裂症患者维持治疗的依从性,使患者生存质量改善。

Objective To investigate the effect of clinical pharmaceutical nursery intervention on maintaining treatment and quality of life in patients with recovery schizophrenia. Mithods 100 cases of recovery schizophrenia patients were divided into the pharmaceutical 50 nursery intervention group and 50 control group accorded to family members＇ wishes. The patients in both groups received antipsychotic drug therapy but the patients in intervention group also received additional clinical pharmaceutical nursery intervention. The clinical outcome was simultaneously evaluated by the scale of brief psychiatric rating scale （BPRS）, the world health organization quality of life-BREF （WHOQOL-BREF）,the compliance of drug treatment, the recurrent rate and re- hospitalization rate at 0,0.3,0.6 and 1.0 years following treatment. Results After one year following treatment, the treatment compliance of the patients was significantly higher in the intervention group than in the control group （P〈0.05）, while the total scores of scale in BPRS, recurrence rate and re- hospitalization rate were significantly lower in the WHOQOL field of physiology, psychology and social relations of the patients, environmental field, were significantly higher in the intervention group than in control group （P〈0.05）, the total scores of scale in BPRS, recurrence rate and re-hospitalization rate were significantly lower in the intervention group than in the control group （1~〈0.01）. Conclusions The intervention of clinical pharmaceutical nursery can secure the treatment adherence of recovery schizophrenia, stabilize the condition, improve quality of life and can be used as an effective means to promote the rehabilitation of non-acute patients with recovery schizophrenia.