鲍曼不动杆菌的临床分布及耐药性分析

Distribution and Drug Resistance of Acinetobacter Baumannii

目的了解医院感染鲍曼不动杆菌的临床分布及耐药性,为临床用药提供依据。方法收集医院2011年1月至2012年6月常规培养检出的258株鲍曼不动杆菌,分析其在临床标本和病房的分布、耐药状况。结果检出258株鲍曼不动杆菌中,标本主要分布以痰液为主,占85.3%;科室分布主要为重症监护病房(ICU)最高,占53.9%,其次为血液内科、神经外科、神经内科,呼吸内科分别占11.6%、10.5%、9.3%、9.3%;鲍曼不动杆菌对氨苄西林、哌拉西林、氨曲南、头孢唑啉、头孢噻肟、头孢他啶、头孢吡肟、庆大霉素、环丙沙星、左氧氟沙星的耐药率均>50.0%,而对多粘菌素耐药率为0.0%。结论鲍曼不动杆菌主要引起呼吸道感染,耐药性严重,应积极预防治疗医院感染,合理使用抗生素,以减少耐药株的上升。

Objective To investigate the distribution and drug resistance ofAcinetobacter baumannii isolates and to provide basis for clinical applicationof antibiotics. Methods The data on 258 strains ofAcinetobacter baumannii by cultured in normal methods from Jan 2011 to Jun 2012 were collected to analyze the changes in clinical specimens and ward distribution and drug resistance. Results Totally 258 strains ofAcinetobacter baumannii isolated, the specimens were mainly obtained from sputum, accounting for 85.3%, Acinetobacter baumarmii isolates were primarily from the Intensive care unit （ICU）, accounting for 53.9%, the next： blood department of internal medicine, neurosurgery department, nerve department and respiratory medicine, accounting for 11.6%, 10.5%, 9.3% and 9.3%, Acinetobacter baumannii to ampicillin, piperacillin, aztreonam, cefazolin, cefotaxime, ceftazidime, cefepime, gentamicin, ciprofloxacin, levofloxacin resistance rate was 〉50.0%, to polymyxin resistance rate was 0.0%.Conclusion Acinetobacter baumannii cause respiratory tract infection, antibiotic resistance is serious, the prevention and control of nosocomial infections should be strengthened, and the antibiotics should be used reasonably, in order to reduce strains resistant to rise.