白细胞介素10与犬急性胰腺炎

INTERLEUKIN-10 IN ACUTE PANCREATITIS

目的 探讨白细胞介素 10 (IL 10 )在犬急性胰腺炎 (AP)中的作用。方法 用ELISA法检测了 11只急性水肿性胰腺炎 (AEP)犬和 12只急性出血坏死性胰腺炎 (AHNP)犬发病前后血清IL 10的活性 ,并与 7只正常对照犬进行比较。结果 AEP犬发病后 2 4小时内血清IL 10活性明显高于AHNP犬 (P <0 .0 1) ,但至 48小时时 ,两组间IL 10活性已无明显差异 ;而对照组犬及实验组犬AP发病前血清中均未检测出IL 10。结论 ①在生理情况下血清中IL 10活性极低或不存在 ;②AHNP犬血清IL 10活性明显低于AEP犬 ,可能系消耗过多所致 ;③在AP早期给予IL 10对减轻胰腺病变的程度 。

HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To evaluate the role of interleukin 10 (IL 10) in acute pancreatitis. [WT5”HZ]Methods [WT5”BZ]Thirty mongrel dogs were divided into three groups based on the severity: acute edematous pancreatitis (AEP) group ( n =11), acute hemorrhagic necrotizing pancreatitis (AHNP) group ( n =12), and control group ( n =7). Serum level of IL 10 was determined with enzyme linked immuno sorbent assay (ELISA). [WT5”HZ]Results [WT5”BZ]Within 24 hours, AEP group had serum level of IL 10 significantly higher than that of AHNP group. Control group had no detectable serum IL 10. No significant difference was observed between AEP group and AHNP group at 48 hours. [WT5”HZ]Conclusion [WT5”BZ]The finding of low values of serum IL 10 suggests that there may be more consumption in AHNP group than in AEP group and it may be beneficial to decrease the severity of experimental acute pancreatitis. [HT6,5”] [WT5”HZ]