甲状腺肿瘤标记物研究进展

THE ADVANCE OF MARKERS FOR THYROID NEOPLASM

目的 探讨对甲状腺肿瘤的诊断及预后判定具有临床意义的标记物。方法 用文献综述的方法对多种标记物在甲状腺肿瘤中的表达及意义进行讨论。结果 CD2 6及半乳糖凝集素 3对分化性甲癌比较特异 ,可作为其术前诊断的一种较简单、可靠的标记物 ;CD97则对未分化甲癌及伴有转移的甲状腺癌比较特异 ;CD15及端粒酶活性检测则可应用于甲状腺包块的针吸细胞学 (FNAB)检查 ,可进一步提高FNAB诊断的正确率 ;RET/PTC则主要有助于对甲状腺髓样癌的诊断 ;癌胚纤维连接蛋白则对乳头状癌及退行性癌特异 ;甲状腺过氧化物酶有助于鉴别甲状腺良、恶性肿瘤。结论 甲状腺癌肿瘤标记物有很多 ,但目前尚缺乏对甲状腺癌的某一种组织类型完全特异的标记物 。

HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To evaluate the markers which contribute to diagnosis and prognosis of thyroid neoplasm. [WT5”HZ]Methods [WT5”BZ]The references about thyroid markers in recent years were reviewed. [WT5”HZ]Results [WT5”BZ]CD 26 and galectin 3 could be regarded as a simple, potent markers to differentiate thyroid carcinoma in preoperative diagnosis, CD 97 was a specific marker for undifferentiated thyroid carcinoma and its metastasis, CD 15 and telomerase could be used in fine needle aspirate biopsy (FNAB) of thyroid mass, and to improve its diagnostic evaluation, RET/PTC was mainly expressed in thyroid medullary carcinoma, oncofetal fibronectin (oncFN) was specific to papillary and anaplastic carcinoma, thyroid peroxidase was used to identify benign and malignant thyroid tumor. [WT5”HZ]Conclusion [WT5”BZ]Although there are a lot of markers for thyroid neoplasm, but there is no marker which are completely specific to certain histotype of thyroid neoplasm at present. [HT6,5”] [WT5”HZ]