西藏水苏的抗焦虑活性(英文)

Anti-anxiety activity of Stachys tibetica Vatke

瞄准 S。tibetica Vatke 是在世界的热带、副热带的区域散布的植物，包括西藏，中国，和印度。在它在 Kargil 的冷荒芜的区域被发现的印度， Ladakh 山谷，并且在 Himachal Pradesh 的山脉。在 Kargil 和 Ladakh 的传统的专业人员为各种各样的心理混乱和恐惧的处理使用自然的药 Stachys tibetica。现在的学习针对在老鼠评估根，茎，叶，和 Stachys tibetica Vatke 的整个工厂材料的 methanolic 摘录的 anxiolytic 效果。每植物部分的方法粉状的材料(1 kg ) 与甲醇(95%) 在一台 Soxhlet 仪器受到抽取；分别地产出 12.8% ， 8.3% ， 17.2% ，和 19.6% W/W extractives。摘录为他们用提高的正迷宫(EPM ) 的效果在老鼠测试的 anxiolytic 被评估。在礼品的结果学习， methanolic 提取，这被发现(200 和 400 mgred 到健康控制题目。方法 49 个病人(意味着年龄 41 他在 Cu-Zn-Zr 之中的协同作用将在 K-Cu/Zn/La/ZrO2 催化剂的活动有重要效果。锻烧温度什么时候是 450 污敵 ? 慷 ? 桴 ? 楨桧獥 ? 湯搠祡? 漠 ? 敲牦杩牥瑡摥猠潴慲敧椠 ?? 猠瑡癩浵昭獩 ? 潣汬条湥礭杯牵 ????? 牃湯慢档 ? 愠摮琠敨挠楲整楲湯爭汥瑡摥瘠污摩瑩 ? 景琠敨焠敵瑳潩湮楡敲眠獡攠慶畬瑡摥琠牨畯桧愠獳' 覒 X 楴湯?敢睴敥?桴?楤???訬? 訬 ？？

AIM： S. tibetica Vatke is a herb distributed in the tropical and subtropical regions of the world, including Tibet, China, and India. In India it is found in the cold desert regions of Kargil, Ladakh Valley, and in the mountains of Himachal Pradesh. The traditional practitioners in the Kargil and Ladakh use the natural medicine Stachys tibetica for the treatment of various mental disorders and phobias. The present study is aimed at evaluating the anxiolytic effects of the methanolic extract of the root, stem, leaf, and whole plant material of Stachys tibetica Vatke in rats. METHODS： Powdered materials （1 kg） of each plant part were subjected to extraction in a Soxhlet apparatus with methanol （95%）; to yield 12.8%, 8.3%, 17.2%, and 19.6% W/W extractives, respectively. Extracts were evaluated for their anxiolytic effects using the elevated plus maze （EPM） test in rats. RESULTS： In the present study, it was found that the methanolic extracts （200 and 400 mg·kg 1 ） of the root, stem, leaf and whole plant of Stachys tibetica Vatke and diazepam （DZ） increased the time spent and the number of entries in the open arm significantly （ ＊＊ P 〈 0.01）, while they decreased the time spent and the number of entries in the closed arm. At the same time, all of the extracts and DZ decreased the time spent at the center of the maze （latency）, along with closed arm returns. The head dip counts increased significantly in the rats treated with DZ, SMR400, SML400 and SMW400 in the open arm of EPM, which was a sign of reduction anxiety. The DZ and SMW did not show the fecal bolus, while other groups had reduced fecal bolus （ ＊＊ P 〈 0.01） as compared to control. These allied parameters helped to assess the anxiolytic potential of Stachys tibetica Vatke. Whole plant and leaf materials have shown the maximum activity, the root intermediate while the stem had the least anxiolytic activity （ ＊ P 〈 0.05, ＊＊ P 〈 0.01） in EPM. CONCLUSION： The results strongly justify the use of this plant for the treatment of anxiety. Further studies are in progress in this laboratory to isolate and identify the components responsible for the anxiolytic activity and the mechanism of action involved.