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^(18)F-FDG PET图像中肿瘤非均匀性评估模型 被引量：1

Intra-Tumoral Heterogeneity Assessment Model in ^(18)F-FDG PET Images
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摘要 肿瘤在功能图像中表现出的非均匀特性能够一定程度上反应出其基本特性和对治疗的响应,对这一特性的数学描述和建模可为治疗和预估治疗效果提供有意义的量化参考数据.本文提出一种新的放射性同位素氟18标记的脱氧葡萄糖(18F-FDG)正电子发射断层影像(PET)中肿瘤内部非均匀性计算模型,通过图像中相邻像素的FDG标准摄取值(SUV)差异和其位置特征,可得出能描述肿瘤图像呈现的非均匀特性的参数H指数.使用矩形和高斯球模体以及3例肺癌患者数据,通过与灰度共生矩阵(GLCM)图像分析法比较研究,验证了该模型的有效性. The intra-tumoral heterogeneity information of cancers from functional images can reflect their basic characteristics and responses to treatment. Mathematical illustration and modeling of this character- istic will provide effective ways for the quantitative analysis of the responses. A new model is proposed to assess tumor heterogeneity by summing up the voxel-wise distribution of differential standard uptake value （SUV） of fluorodeoxyglucose （FDG） from the 18F-FDG positron emission tomography（PET） image data. Based on square testing graphics, spherical phantoms and the lSF-FDG PET image data of 3 lung cancer patients, the new model with the H index was compared with a widely-used model of gray level co-occur- rence matrix （GLCM） for image texture characterization, thus verifying its effectiveness.
作者 冯远明 李崇崇 张珺 王平
机构地区 天津大学精密仪器与光电子工程学院 天津医科大学附属肿瘤医院
出处 《纳米技术与精密工程》 CAS CSCD 2013年第3期247-251,共5页 Nanotechnology and Precision Engineering
基金 国家科技支撑计划资助项目(2012BAI15B01)
关键词 肿瘤 非均匀性 评估模型 18F-FDG PET 灰度共生矩阵 tumor heterogeneity assessment model 18F-FDG PET gray level co-occurrence matrix
分类号 TP391.41 [自动化与计算机技术—计算机应用技术] R730.44 [医药卫生—肿瘤]
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参考文献16

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二级参考文献13

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纳米技术与精密工程
2013年 第3期

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