银杏叶片治疗男性长期住院精神分裂症患者注意记忆损害的对照研究

Long-term Hospitalized Male Schizophrenic’ Attention and Memorization Damage with Gingko Leaf

目的评价银杏叶提取物对男性长期住院精神分裂症患者注意、记忆损害的影响。方法 120例男性长期住院精神分裂症患者随机分为两组,每组60名,均服用利培酮片治疗,研究组合并银杏叶片治疗,观察12周。应用重复性成套神经心理状态测验(RBANS)中Stroop色词测验(SCW)、持续操作测验(CPT)、数字序列测验、言语记忆及视觉记忆测验测查治疗前后患者的注意力和记忆力。结果治疗12周末,研究组患者在Stroop色词测验(SCW)、持续操作测验(CPT)正确反应数、数字序列测验、言语记忆测验、视觉记忆测查5个方面的均有不同程度的改善(t=-2.09,-3.40,-2.38,-3.72,-2.01;P<0.05)。与对照组比较,研究组在持续操作测验(CPT)正确反应数、数字序列测验、视觉记忆测查、言语记忆测验4个方面均有明显差异,并具有统计学意义(t=2.61,2.62,2.21,2.83;P<0.05)。Stroop色词测验(SCW)、持续操作测验(CPT)正确反应时间无明显差异(t=1.92,-1.62;P>0.05)。结论银杏叶提取物与抗精神病药物合用能够改善长期住院慢性精神分裂症患者的注意力和记忆力,能够做为增效剂在治疗以阴性症状为主或认知功能损害明显的精神分裂症患者中应用。

Objective To evaluate the effect of gingko leaf on long-term hospitalized male schizophremc attention and memo rization damage. Methods A total of 120 long-term hospitalized male schizophrenic were divided into two groups randomly. They all took risperidone tablets for 12 weeks,while patients in experimental group took gingko leaf at the same time. To inspect the at- tention and memorization of patieats before and after the treatment through SCW,CPT,digital sequence test,verbal and visual memory test in RBANS. Results At the end of the 12th week,patients in experimental group improved inordinately at all the SCW, CPT right reactions, digital sequence test, verbal and visual memory test （t =-2.09,-3.40,-2.38,-3.72,-2.01 ） P〈 0.05 ）. Compared with control group,there were great differences before and after the treatment in the CPT right reactions,digital se- quence test ,verbal and visual memory test （t ： 2, 61,2.62,2.21 2.83, P〈0.05）. There were no obvious differences in SCW and CPT correct reaction time （t= 1. 92,-1. 62）P〉 0. 05）. Conclusion The combination of ginkgo leaf extract with antipsychotic drugs will improve the long-term hospitalized male schizophrenic＇ attention and memorization,and may be applied as synergist on the schizophrenics mainly with negative symptoms or have obvious cognitive function damage.