聚合物基抗癌药物载体的研究进展

Review of the Polymeric Anticancer Drug Delivery System

癌症是导致世界死亡率居高不下的主导原因之一,利用抗癌药物,采用化学疗法治疗癌症是目前较为有效的方法之一。为了提高抗癌药物在体内的溶解性,增大药物在癌细胞内的累积量,增强对癌细胞的杀伤性,减小对正常组织细胞造成的毒害作用,抗癌药物载体从简单的抗癌药物-聚合物复合物、聚合物胶束、纳米粒子等简单结构逐渐向具有靶向性、环境刺激响应性、表面电荷反转性等特性的新型结构发展。本文综述了国内外抗癌药物载体的发展历程以及最新进展,着重对新型载体的制备和研究进行了论述。

Cancer is one of the main reasons of the world＇s high death rate. Chemical treatment would be the most effective way to remedy cancer. In order to promote the intracorporal dissolvability and intracellular cumulant of anticancer drugs, the destruction to cancer cells as well as to decrease the damage to normal tissues, the anticancer drug delivery system develops from simple carriers, like conjugations of anticancer drug and polymer, polymer micelles, simple nanoparticles, to advanced delivery system with properties of targeting, responding to environmental stimulation as well as charge reversal. This article mainly talks about the development progress of anticancer drug delivery system and highlights the preparation and theoretical research of new designed anticancer drug delivery system.