肿瘤与静脉血栓栓塞症

Cancer and venous thromboembolism

静脉血栓栓塞症(VTE)是肿瘤患者死亡的主要原因和重要并发症。VTE发病机制与肿瘤细胞表达各种促凝物质引起的高凝状态和化学治疗导致的血管内皮损伤有关。患者相关危险因素、肿瘤相关危险因素和治疗相关危险因素均可导致VTE的发病率增加,但多数肿瘤科医生仍然低估了肿瘤患者VTE的发病率及其对患者结局的影响。文章强调应当增强其对肿瘤合并VTE的防控意识,重视对肿瘤患者危险因素的评估,及时诊断和采取预防措施,减少VTE的发生。

Venous thromboembolism （VTE） represents one of the most important causes of morbidity and mortality in cancer patients. Hypercoagulability, stasis and vessel wall injury, which are the mechanisms of VTE, are associated with cancer or chemotherapy. There are several factors that might increase the risk of VTE,including those related to patients themselves, cancer or treatments. But most of oncologists have underestimated the prevalence of VTE and its negative impact on their patients. Measurements should be taken to enhance the perceptions about magnitude of VTE risk in patients with malignancy and to improve prophylaxis and treatment of VTE in cancer patients.