克林沙星的7-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸路线合成

Synthesis of Clinafloxacin

由环丙沙星中间体 7-氯 - 1-环丙基 - 6 -氟 - 1,4-二氢 - 4-氧代 - 3-喹啉羧酸为原料 ,经与 3-乙酰胺基吡咯烷缩合、氯化、水解去乙酰基得克林沙星 ,总收率 2 1.3%。

Clinafloxacin was synthesized by condensation of 1 cyclopropyl 6 fluoro 7 chloro 1,4 dihydro 4 oxo 3 quinolinecarboxylic acid with 3 acetamidopyrrolidine, chlorination and then hydrolysis in an overall yield of 21.3%.