血清中血管生成因子2的浓度与慢性阻塞性肺疾病急性加重的关系

Relation between serum concentration of angiopoietin-2 and acute exacerbation of chronic obstructive pulmonary diseases

目的研究患者血清中血管生成因子2（Ang2）浓度与慢性阻塞性肺疾病急性加重（AEcOPD）之间的关系。方法采用ELISA法检测血清中Ang2的浓度。血清标本分别来源于50例AECOPD患者，50例COPD稳定期患者和50名健康人。结果AECOPD患者血清Ang2浓度是（3861．6±273．8）ng／L，COPD稳定期患者Ang2浓度是（2107．4±843．4）ng／L，健康人血清Ang2浓度是（1645．7±453．2）ng／L。AECOPD患者血清中Ang2浓度显著高于COPD稳定期患者及健康人（P〈O．01）。结论AECOPD患者血清中Ang2浓度显著升高，Ang2有望成为评价AECOPD的一个有用的生物标记物。

Objective To study the relation between the serum angiopoietin-2 （Ang2） and acute exacerbation of chronic obstructive pulmonary diseases （AECOPD）. Methods Using ELISA, serum concentration of Ang2 were measured in 50 patients with AECOPD,50 patients with stable COPD and 50 healthy control subjects. Results Serum Ang2 concentrations were （3 861.6 ±273.8） ng/L in patients with AECOPD,（2 107.4±843.4） ng/L in patients with stable COPD and （1 645.7±453.2） ng/L in healthy control subject. Serum Ang2 in patients with AECOPD were significantly higher in patients with AECOPD than both patients with stable COPD and healthy control subjects （ P 〈0.01）. Conclusions Serum Ang2 were significantly increased in AECOPD, and it might be a useful biomarker for this disease.