肺表面活性蛋白及其在慢性阻塞性肺疾病中的研究进展

Advances of surfactant proteins in chronic obstructive pulmonary disease

肺表面活性蛋白（SPS）是肺泡表面活性物质的重要组成部分，主要在肺部产生，由Ⅱ型肺泡细胞分泌。SPS不仅参与调节肺泡表面张力、维持肺泡稳定性，还在宿主免疫调节中发挥着重要的作用。研究SPS在慢性阻塞性肺疾病中的表达及作用机制，可能为慢性阻塞性肺疾病的诊治及病情监测提供新方法。

Surfactant proteins （SPs） are important components of the pulmonary surfactant. They are mainly in the lungs and secreted by type II alveolar cells. SPs not only involved in the regulation of alveolar surface tension for stability, but also play an important role in host immunomodulation. The study of their expression and mechanism in chronic obstructive pulmonary disease may provide a new way for the disease diagnosis, monitoring and treatment.