肝星状细胞与血吸虫病肝纤维化

Hepatic stellate cells and schistosomiasis liver fibrosis

肝纤维化是包括血吸虫感染在内的各种慢性肝脏损伤的共同的最终病理结局。静息状态的肝星状细胞（hepatic stellate cells，HSC）激活成具有增殖、收缩和致纤维化作用的肌成纤维细胞是肝纤维化发生发展的关键步骤。近年来，HSC被证明在人和小鼠血吸虫病肝纤维化中发挥重要作用。HSC在血吸虫病肝纤维化中的功能以及血吸虫虫卵与HSC相互作用的研究有助于更好地理解血吸虫病肝纤维化发生发展的机制．为治疗和预防血吸虫病肝纤维化提供新思路、新方向。

Liver fibrosis is a common outcome of chronic liver injuries including Schistosoma infection. Activation of resident hepatic stellate cells （HSC） into proliferative, contractile, and fibrogenic myofibrosblast is considered the key process driving liver fibrosis. Recent studies have highlighted that HSC plays an important role in both murine and human schistosomiasis liver fibrosis. Studies of the HSC and its interaction with Schistosoma eggs may be pivotal in our understanding of the pathology associated with schistosomiasis liver fibrosis and provide new approaches to prevent and treat schistosomiasis liver fibrosis.