摘要
脂联素（Acrp30）是1996年由Sherer发现的一种内源性生物活性多肽，可通过AMPK、P13K／Akt／roTOR、JNK—START3、WntB—catenin等信号通路选择性地抑制乳腺癌、前列腺癌、卵巢癌等多种恶性肿瘤细胞增殖、侵袭转移、炎性反应及血管生成。脂联素与肺癌的病理分期、炎症反应、血管生成密切相关，但脂联素在肺癌等多种癌症中的作用及作用机制目前仍存较多争议，进一步探明脂联素与肺癌的增殖、侵袭、转移及血管生成的关系可为治疗肺癌提供新的思路。
Adiponectin （Acrp30）,a kind of endogenous bioactive peptides found by Sherer in 1996, could selectively inhibit the proliferation, invasion or metastasis, inflammatory response and angiogenesis of various malignant tumors including breast cancer, prostate cancer, and ovarian cancer through different signaling pathways such as AMPK, PI3K/Akt/mTOR, JNK-START3, Wnt-β-catenin signaling pathways. Adiponectin is greatly related to pathological stages, inflammatory reactions, angiogenesis of lung cancer. However, the detailed effects and its mechanisms of adiponectin in lung tumor and other tumors have not been stressed, and exploring the specific role of adiponectin in lung cancer may provide new ideas for the treatment of lung cancer.
出处
《国际呼吸杂志》
2013年第10期784-789,共6页
International Journal of Respiration
关键词
脂联素
肺癌
侵袭
转移
炎症
血管生成
Adiponectin
Lung cancer
Invasion
Metastasis
Inflammation
Angiogenesis
