米非司酮用于子宫内膜异位症术后临床探讨

目的:了解子宫内膜异位症术后服用米非司酮的疗效和安全性。方法:回顾性分析135例子宫内膜异位症患者行保守性手术治疗后的随访资料,术后应用米非司酮68例为研究组,未用药组67例为对照组,比较两组的症状体征、复发率、不良反应及妊娠情况。结果:研究组复发率7.4%,显著低于对照组的47.8%(P<0.05);研究组不孕症的术后妊娠率为38.1%,显著高于对照组的22.2%(P<0.05)。结论:小剂量米非司酮用于子宫内膜异位症术后的巩固治疗是有效的,不良反应少,妊娠率高。

Objective：To investigate the endo- metriosis postoperative tse of efficacy and safety of mifepristone. Methods ： A retrospec- tive analysis of follow - up data of 135 cases of conservative operation for treatment of en- dometriosis after, after mifepristone treat- ment for 68 cases of the study group, un- treated group and 67 cases as control group, compared with two groups of symptoms and signs, recurrence rate, side reaction and pregnancy. Results：The study group the re- currence rate was 7.4% , significantly lower than the control group 47.8% （ P 〈 0.05 ） ; the study group with postoperative pregnancy rate was 38. 1%, significantly higher than that of the control group 22. 2% （P 〈 0. 05）. Conclusion ： Small dose of mifepristone for consolidation therapy after surgery of en- dometfiosis is effective, less side reaction, high rate of pregnancy.