幽门螺杆菌感染与老年消化性溃疡的相关危险因素调查分析

Related risk factors for peptic ulcer in elderly patients with Helicobacter pyloriinfections

目的探讨幽门螺杆菌(HP)感染与老年消化性溃疡的相关危险因素,为老年消化性溃疡的防治提供参考。方法共纳入300例老年HP感染患者,根据患者是否发生消化性溃疡分为两组,详细记录所有患者的基本信息,应用多因素回归分析进行统计分析。结果 300例HP感染的老年患者中,有80例老年患者出现消化性溃疡;单因素分析结果显示,发生溃疡患者平均年龄(68.7±4.7)岁,明显高于未发生溃疡患者的(63.1±3.0)岁,且吸烟史、饮酒史、药物治疗史、生活规律及体重指数与HP感染的老年患者发生消化性溃疡存在相关性,两组比较差异有统计学意义(P<0.05);根据临床知识及单因素分析结果,对相关因素进一步行多因素回归模型分析,结果显示,高龄、既往有吸烟史是HP感染的老年患者发生消化性溃疡的独立危险因素(P<0.05),而生活规律是其保护因素,可以减低HP感染的老年患者发生消化性溃疡风险(P<0.05)。结论 HP感染的老年患者发生消化性溃疡受到年龄及吸烟史的影响,而生活规律的老年HP感染患者,其发生消化性溃疡的风险较小,在临床护理工作中,对于可干预因素进行必要的干预有重要的意义。

OBJECTIVE To explore the related risk factors for chronic peptic ulcer in the elderly patients with Helicobacter pylori（HP） infections so as provide basis for the prevention of peptic ulcer in the elderly patients. METHODS A total of 300 elderly patients with HP infections were enrolled in the study and were divided into two groups according to the chronic peptic ulcer; the basic information of all the patients was recorded in detail, and the statistical analysis was performed through the multivariate regression analysis. RESULTS Of 300 cases of elderly patients with HP infections, the chronic peptic ulcer occurred in 80 cases; the univariate analysis indicated that the average age of the patients with the peptic ulcers was （68.7±4.7） years old, significantly higher than （63.1±3.0） years old of the patients without peptic ulcer and that the smoking history, drinking history , drug treatment history, daily routine and BMI were the factors associated with the chronic peptic ulcer, the difference was statistically significant（P〈0.05） ; according to the clinical knowledge and the result of univariate analysis, the multivariate regression analysis showed that the advanced age, and the smoking history were the independent risk factors for the chronic peptic ulcer in the elderly patients（P〈0.05）, and regular daily routine was the protective factor and could reduce the risk of chronic peptic ulcer in the elderly patients with HP infections （P〈0. 05）. CONCLUSION The emergence of peptic ulcer in the elderly patients with HP infections is prone to be influenced by the age and the smoking history, however, the peptic ulcer is less likely to occur in the elderly patients with HP infections who lead a regular daily life. It is of great significance to perform the necessary interventions to the risk factors.