嗜酸性硫杆菌抗铜机制研究进展

Advance on study of copper-resistance mechanism in Acidithiobacillus spp.

嗜酸性硫杆菌是一类重要的浸矿微生物,其抗铜机制研究备受人们关注。本文在分析相关文献的基础上,从嗜酸性硫杆菌对铜的耐受能力、细胞质中铜的外排、细胞周质中铜浓度的控制、无机多聚磷酸盐参与铜的解毒、新发现的基因组岛和氧化压力应激反应等方面对当前的研究进展进行综述,并对未来相关研究方向做出展望,旨在为嗜酸性硫杆菌抗铜机制的深入研究提供参考。

Acidithiobacillus spp. is important for bioleaching because of the copper-resistance mecha-nism. Many data suggest that Acidithiobacillus spp.’s tolerance to copper is much higher than common bacteria. In the present paper, we reviewed the current knowledge on cop-per-resistance mechanism in Acidithiobacillus spp., including： eliminating copper from the cytoplasm of the cells; reducing copper concentration in the periplasm; a polyphosphate-based copper-resistance system; a newfound genomic island and an oxidative stress response gener-ated by copper. Furthermore, we discussed methods in transcription-regulation and pro-tein-function, to address future research needs.