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MicroRNA在血小板产生和激活中的作用 被引量：3

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摘要 MicroRNA(miRNA)是调节蛋白表达的小分子非编码RNA在各种生理和病理过程中发挥重要作用。最近研究表明,大量的miRNAs如miR-150、miR-155、miR-146a、miR-27a等,在巨核细胞细胞核的分化成熟、巨核细胞胞浆内颗粒脱落形成血小板、血小板成熟并具有活性的过程中发挥重要作用。由于血小板中也具有功能完整的miRNA调控机制,因此某些miRNA在血小板的表达水平与血小板特异性激动以及病理状态的反应性相协调。该文对miRNA在巨核细胞分化和血小板功能中的研究进行概述。
作者 丁雪燕 宋晓伟 荆清 秦永文
机构地区 南京军区杭州疗养院海勤疗区特勤科 第二军医大学长海医院心血管内科
出处 《国际心血管病杂志》 2013年第3期161-163,177,共4页 International Journal of Cardiovascular Disease
关键词 MICRORNA 巨核细胞 血小板
分类号 R331 [医药卫生—人体生理学]
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参考文献28

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同被引文献33

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33037
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国际心血管病杂志
2013年 第3期

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