酒精性肝病患者血清中天门冬氨酸氨基转移酶线粒体同工酶水平及临床价值

Levels of Aspartate Aminotransferase Enzyme Mitochondrial Isoenzyme in the Serum of Patients with Alcoholic Liver Disease and Its Clinical Value

目的探讨酒精性肝病患者血清中天门冬氨酸氨基转移酶线粒体同工酶水平及其用于临床诊断的价值。方法选取酒精性肝病患者117例作为A组,乙肝病毒性肝病患者112例作为B组,健康体检者100例作为C组,使三组患者有可比性。抽取三组患者治疗前或体检当天空腹血以及A组患者治疗3周后空腹血,分别行m-AST、ALT、AST以及GGT水平检测。结果 A、B两组患者m-AST、ALT、AST、GGT水平均明显高于C组,且B组明显高于A组;经过治疗不同类型的酒精性肝病患者m-AST、ALT、AST和GGT水平均明显降低。上述比较差异明显,有统计学意义(P<0.05)。结论血清m-AST是临床检测酒精性肝病的良好而重要的指标。

Objective To investigate the levels and clinical value of aspartate aminotransferase enzyme mitochondrial isoenzyme in the serum of patients with alcoholic liver disease. Methods 117 cases of patients with alcoholic liver disease were chosen as Group A; 112 cases of liver disease patients with hepatitis B virus were set as the Group B; and 100 cases of healthy persons were set as Group C. Three groups were comparable. The fasting blood of people in the three groups before treatment or medical examination, and the fasting blood of the patients in Group A at three weeks after the treatment were extracted and taken with m-AST, ALT, AST and GGT levels detection. Results The m-AST, ALT, AST, GGT levels in Group A and Group B were significantly higher than those in Group C; and they were significantly higher in Group B than in Group A. The levels of m-AST, ALT, AST and GGT in alcoholic liver disease patients significantly reduced after different types of treatment, with statistically significant difference （P 〈0.05）. Conclusions Serum m-AST is an important indicator in clinical monitoring of alcoholic liver disease.