3项联合检测在原发性高血压诊断中的临床价值

Clinical values on D-dimer,fibrinogen and high-sensitivity C-reactive protein detection in the diagnosis of essential hypertension

目的研究原发性高血压(EH)患者血浆中的D-二聚体(D-D)、纤维蛋白原(Fib)和超敏C-反应蛋白(hs-CRP)浓度水平变化以及3项指标在EH诊断中的临床价值。方法检测108例各级EH患者和44例健康人的血浆D-D、Fib和hs-CRP水平,血浆D-D测定采用酶联免疫吸附试验,Fib测定采用磁珠法,hs-CRP测定采用免疫透射比浊法。结果血浆D-D水平在1级EH时无明显升高,差异无统计学意义(P>0.05),在2级EH和3级EH显著升高,差异有统计学意义(P<0.01);Fib水平在1级EH时无明显升高,差异无统计学意义(P>0.05),2级和3级时显著升高,差异有统计学意义(P<0.01);hs-CRP水平在各级EH患者间比较差异均有统计学意义(P<0.01)。另外各级EH患者的3项指标有良好的相关性(r分别为0.784、0.631、0.721)。结论对EH患者的D-D、Fib和hs-CRP的进行联合检测,能较好地反映EH患者的病情发展程度,为其早期诊断和治疗提供可靠依据。

Objective To study plasma D- dimmer （D-D）,fibrinogen（Fib） and high-sensitive C- reactive pro- tein（hs-CRP） concentration changes in essential hypertension （EH） patients and clinical values on correlation be- tween the three indicators in the diagnosis of EH. Methods Plasma D-D,Fib and hs-CRP concentrations were detec- ted in 108 cases of patients with EH at all levels and 44 cases of healthy subjects. Plasma D-D was measured by ELISA , Fib was determined by immunomagnetic beads method and hs-CRP was detected by immunological trans- mission turbidimetry. Results Plasma D-D in level 1 EH was not increased significantly （P^O. 05）. Plasma DD in level 2 EH and in level 3 EH were significantly increased （P^0.01）. Fib in level 1 EH was not significantly in- creased （P^0.05）. Fib in level 2 EH and in level 3 EH were significantly increased （P^0.01）. hs-CRP in EH pa- tients at all levels had significant differences （P^0.01）. The three indicators have good correlation in EH patients at all levels （r=0. 784,0. 631,0. 721）. Conclusion D-D, Fib and hs-CRP combined detection could better reflect the condition of patients with EH, which could provide reliable basis in early clinical diagnosis and treatment.