石家庄市中老年代谢综合征现状及其相关因素分析的调查研究

Epidemiological investigation on metabolic syndrome in middle-aged and old people in Shijiazhuang and analysis on its influence factors

目的探讨石家庄市中老年人群MS的患病情况及其影响因素。方法分层随机抽样选择石家庄市9个社区,居住≥5年、年龄≥45岁的居民,对其进行流行病学调查和体格检查,检测FPG、HbA1c、血脂及OGTT等指标。结果 MS患病率为21.2%,其中男6.4%,女14.8%;65岁以上患病率为24.8%及65岁以下为19.7%(P<0.05或P<0.01);65岁以下患病率男5.7%,女14.1%;65岁以上患病率男8.3%,女16.5%(P=0.01)。以HbA1c 6.5%为切点,MS患病率分别为59.7%和14.1%(P<0.01)。NGT、DM、IFG、IGT、IFG+IGT组间比较,MS患病率差异均有统计学意义。年龄、性别、糖尿病家族史、喜食甜食、BMI、WHR、TG、HDL-C、SBP、DBP、FPG、2hPG、HbA1c为患MS的危险因素。结论石家庄市MS患病率有性别及年龄差异。BMI、WHR,血脂、血压及HbA1c监控、糖代谢状态筛查有助于MS的诊断及预防。

Objective To investigate the epidemiologic profile and influence factors of metabolic syndrome of middle-aged and old people in Shijiazhuang. Methods A cross-sectional epidemiological investigation was performed. The middle-aged and old people in the city of Shijiazhuang （age≥45 years） in nine communities were investigated. A total of 1447 subjects （509 males and 938 females） were included.After an overnight fasting, each participant underwent epidemiological surveys, physical examination,fasting plasma glucose and serum lipid tests,and oral glucose tolerance test （OGTT）. The prevalence of MS and its attributing factors were analyzed by logistic regression model. Results The prevalence of metabolic syndrome was 21.2%% in Shijiazhuang （male 6.4%, female 14.8%, χ2=4.075, P=0.044; ≥65 years old 24.8%, 〈65 years old 19.7%, χ2=4.651, P=0.031）. The prevalence of metabolic syndrome was 14.8% in female aged 〈65 years,while in male aged 〈65 years was 8.3% （χ2=14.67, P〈0.01）. The prevalence of metabolic syndrome was 8.5% in female aged ≥65 years,while in male aged ≥65 years was 16.5% （χ2=10.08, P=0.01）. The prevalence of metabolic syndrome increased with age for male,while not for female. The prevalence of metabolic syndrome was different for different HbA1C profile （HbA1c≥6.5% vs HbA1c〈6.5%, 59.7% vs 14.1%, χ2=237.732, P〈0.01）. The comparisons among the NGT, DM, IFG, IGT and IFG＋IGT groups showed that the prevalence of metabolic syndrome was significantly different. The multivariable stepwise analysis extracted the age, sex, family history of diabetes, preference for sweet foods, body mass index, waist-to-hip ratio, plasma triglyceride, low-density lipoprotein cholesterol, systolic blood pressures, diastolic blood pressures, fasting plasma glucose, 2-h postprandial blood glucose, and hemoglobin A1c as the major risk factors for metabolic syndrome. Conclusion The prevalence of metabolic syndrome is high in Shijiazhuang. The prevalence of metabolic syndrome is different for different genders and ages. The observation on BMI, WHR, lipid levels, blood pressure levels, glycometabolic state, and HbA1c helps the diagnosis and prevention of metabolic syndrome.