Ghrelin基因Leu72Met多态性与2型糖尿病相关性的Meta分析

A Meta-analysis on the association between ghrelin Leu72Met gene polymorphism and type 2 diabetes mellitus

目的采用Meta分析评价Ghrelin基因SNP+408C/A位点多态性与T2DM的相关性。方法检索中国知网、维普、万方、Pubmed、Cochrone library、OVID数据库,收集2000年1月至2012年5月公开发表的有关Ghrelin基因SNP+408C/A位点多态性与T2DM相关性研究的文献;按一定标准对文献质量进行综合评价,提取有效数据,采用Review Manager 5.1软件进行Meta分析。结果共纳入研究8篇,累计病例3944例,对照3967例。Meta分析结果显示,Ghrelin基因+408C/A位点多态性与T2DM的相关性中C等位基因与A等位基因(OR:1.02,95%CI:0.93～1.12,P=0.61)、基因型CC与(CA+AA)(OR:0.99,95%CI:0.89～1.10,P=0.80)、基因型CC与CA(OR:0.98,95%CI:0.88～1.10,P=0.73)、基因型CC与AA(OR:1.2,95%CI:0.90～1.60,P=0.22)比较,差异均无统计学意义。结论 Ghrelin基因+408C/A位点多态性与T2DM易感性可能无关。

Objective To investigate the association of ghrelin ＋408C/A polymorphism with T2DM. Methods A systematic review and Meta-analysis were undertaken to investigate previous findings and evaluate the relationship between ghrelin genetic polymorphism and susceptibility to T2DM. All studies matched to search terms from the CNKI, VIP, Wanfang database, Pubmed, Cochrane library, and Ovid that had been published before May 2012 were retrieved for obtaining the qualified articles. Then the articles were checked independently by 2 investigators according to the inclusion and exclusion criteria. Meta analysis was performed by using Review Manager 5.1 software. Results A total of 3944 cases and 3967 controls from 8 studies were included. Meta analysis indicated that, in the association of ghrelin ＋408C/A polymorphism with T2DM, there was no statistical difference between C allele and A allele （OR=1.02, 95%CI=0.93-1.12, P=0.61）, genotype of （CA＋AA） and CC （OR=0.99, 95%CI=0.89-1.10, P=0.80）, genotype of CA and CC （OR=0.98, 95%CI=0.88-1.10, P=0.73）, and genotype of AA and CC （OR=1.2,95%CI=0.90-1.60,P=0.22）. Conclusion Ghrelin gene Leu72Met polymorphism might be not associated with T2DM susceptibility.