磷酸化Olig1和Olig2参与少突胶质细胞发育调控作用的研究进展

Progress of phosphorylated Olig1 and Olig2 in regulation of oligodendrocyte development

少突胶质细胞(oligodendrocytes,OLs)是中枢神经系统(central nervous system,CNS)髓鞘形成细胞。转录因子Olig1和Olig2在OLs的发育、分化和髓鞘形成过程中具有重要作用,如Olig2主要参与少突胶质前体细胞(oligodendrocyte progenitor cells,OPCs)的早期定向分化;而Olig1主要在OLs的成熟分化和髓鞘形成的终末阶段发挥作用。最近研究发现,在OLs发育过程中,Olig1和Olig2可发生磷酸化修饰,而且其磷酸化状态的动态变化参与OLs早期命运决定、细胞增殖以及核浆转位等的调控。对Olig1和Olig2的磷酸化修饰的特点和功能作一综述。

Oligodendrocytes （OLs） are myelin-forming cells in central nervous system （CNS）. Olig1 and Olig2, the bHLH transcription factors, play key roles in manipulating the development of OLs and myelination. Olig2 is essential for cell fate decision in the early stage of oligodendrocyte progenitor cells （OPCs）, while Olig 1 promotes the transcription of myelin-specific genes and promotes terminal differentiation and （re）myelination. Recent studies indicate that different phosphorylated sites endue Olig1 and Olig2 with various regulation functions, particularly in cell fate decision, nucleocytoplasmic translocation and proliferation of oligodendrocyte lineage cells.